| ncRNA name | SOS1 siRNA |
| ncRNA Category | siRNA |
| Disease name | uveal melanoma (UM) |
| Species | Homo sapiens |
| Tissues/Cell_line | UM cell line M23 |
| Methods | siRNA transfection, CCK-8 assay, colony formation assay, wound-healing assay, transwell assay |
| Expression pattern | associated |
| Functional description | Knockdown of SOS1 caused an inhibition on M23 cell proliferation, migration, and invasion. Moreover, the phosphorylation levels of MEK and ERK were reduced in UM cells after downregulating SOS1 expression (p < 0.010). |
| PubMed ID | 30714452 |
| Year | 2019 |
| Title | Enhanced expression of son of sevenless homolog 1 is predictive of poor prognosis in uveal malignant melanoma patients. |
| Drug-related ncRNA | NO |
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